In a story based on a popular video game, a woman plagued by temporary memory loss is brought along by commandos on a mission to find out what happened in a top-secret lab (controlled by a sentient computer) where a virus has turned the living into zombies.
The Umbrella Corporation is a multinational giant that has products in almost every household on Earth. While publicly innocuous, Umbrella is conducting experiments of the illegal kind (viral and genetic) in a secure underground facility called The Hive. When a virus they were working on is unleashed, the "Red Queen"--the sentient computer controlling the facility--kills everyone inside, but the virus turns the Hive scientists into zombies. A team of commandos is sent to find out what happened in the Hive--where they will face an angry computer, undead beings and a genetically altered creature, "the Licker," that was made just for killing--and clean up the virus before it takes over the world. The commandos take an amnesiac couple, found at the mansion that hides the entrance to the Hive, along for the ride and find (surprise!) they hold the key to part of the mystery surrounding what happened.